Tributaries of Schoharie Creek, listed from upstream to downstream, include: Before European colonization, the watershed was mostly forested with a few small areas cleared by Native Americans for hunting.

Early European settlers attempted to farm the land, but soon abandoned it due to the short growing seasons, steep slopes and rocky soil.

Between 1800 and the early 1900s, mills, the tanning industry, quarrying for bluestone, logging, railroads, and resorts cleared the Catskills of most of its forest cover.

Biological tests were conducted in Fort Hunter in 2001, then in Burtonsville in 2001, and showed non-impacted water quality conditions at both sites.

[8] Another station by North Blenheim in operation continuously since October 1970, 1.2 miles (1.9 km) upstream from bridge on State Highway 30 in North Blenheim, had a maximum discharge of 111,000 cubic feet (3,100 m3) per second on August 28, 2011, and a minimum discharge of 0.04 cubic feet (0.0011 m3) per second on many days from June to October 1976, and September 11-13, 1980.

[10] The station in Schoharie is located upstream from bridge on County Highway 1A has been in operation since December 2017, takes gauge height measurements only.

By the end of the French and Indian War, they were the one remaining group of eastern native peoples that retained sufficient military power to give even the British authorities pause.

The lower Mohawk valley was a scene of uneasy native Amerindian–Colonial Settler contention throughout most of the 18th century until after the American Revolutionary War's Sullivan Expedition pacified the region by permanently weakening the Six Nations of the Iroquois.

On the morning of April 5, 1987, after 30 years of service, two spans of the New York State Thruway bridge over Schoharie Creek near Fort Hunter collapsed.

[18] Twelve hours before the Schoharie Creek Bridge collapsed due to heavy rainfall, the rush of water through the Blenheim-Gilboa Pumped Storage Power Project 40 miles (64 km) upstream hit a historic high.