Its early prestige can be judged by the fact that its headmaster or director, Ishai at the time, took part in the selection of a new patriarch.
[1] Between 596 and 602, the Roman emperor Maurice sent Maruta, bishop of Chalcedon, as ambassador to the Sasanian king Khosrau II.
The ambassador listened to lectures at the school, gave gifts to the students and was received directions for his return journey from the headmaster, Bokhtisho .
The school appears to have been at the centre of the Christian community in the Sasanian capital if it could host a visiting Roman dignitary.
[1] The Patriarch Ishoyahb III (649–659) studied at Nisibis and tried to move part of the School of Seleucia to the Monastery of Beth Abe, probably to protect it after the fall of the Sasanian Empire to the Arabs.