It flows roughly northeast for a short distance, crossing Pennsylvania Route 154.
In this township, the creek turns east-northeast, receiving the tributary Pine Swamp Run.
[2] It eventually turns roughly northeast, passing near Pennsylvania State Game Lands Number 36.
The channel of the creek is sinuous and rock formations made of shale and sandstone are found in its vicinity.
[6] In the early 1900s, the main industries in the watershed of Schrader Creek were coal mining and agriculture.
During this time period, the Susquehanna and New York Railroad also followed the creek between Wheelerville and its mouth.
[1] It is possible to canoe on 12.7 miles (20.4 km) of Schrader Creek during snowmelt and within several days of heavy rain.
Edward Gertler describes the scenery along it as "good to excellent" in his book Keystone Canoeing.