The station is no longer served by long-distance traffic since the introduction of the Interregio line from Stuttgart via Würzburg and Schweinfurt to Erfurt in 2001.

On the Würzburg–Bamberg route the frequency of RE trains is supplemented by the use of RegionalBahn services; likewise the EIB Linie 5 Schweinfurt–Gemünden (Main), bolsters the section to Bad Kissingen.

The station building at Schweinfurt Hauptbahnhof is on the north side of the tracks.

The two-storey building houses a Deutsche Bahn travel centre (ReiseZentrum), toilets, lockers and several shops.

Two bay platforms directly in front of the station building are no longer needed for scheduled services since trains from Bad Kissingen and Meiningen now pass through the Hauptbahnhof and stop at the more centrally-sited Schweinfurt Stadt station.