[10][11] Science-Based Medicine is owned and operated by the New England Skeptical Society (NESS),[3] where Novella, a clinical neurologist at Yale University[2] and the executive editor of SBM, has served as president since its inception.

[12][13][14] The blog was affiliated with the former Society for Science-Based Medicine (SfSBM),[15] an opinionated education and advocacy group,[16] that registered in 2014[17] as a Florida nonprofit corporation[16][18] led by Mark Crislip.

[28] On June 15, 2021,[29] Science-Based Medicine published a book review of Abigail Shrier's Irreversible Damage written by founding editor Harriet Hall.

[30] In her review, Hall wrote that Shrier's book had raised legitimate concerns about the science surrounding drug treatments for gender dysphoria in children and that there was a lack of quality scientific studies on the subject.

The lawsuit, filed by Tobinick against Novella, the Society for Science-Based Medicine, Inc., and SGU Productions, LLC was resolved after the court ruled in favor of the defendants.