Unlike other high schools in the city, SPHS students take two science courses specific to their academic year.

For 32 years, Science High School was at 40 Rector Street, in a building that was originally the Ballantine Brewery.

After the brewery closed, it was acquired by Rutgers–Newark and was converted into a facility for chemistry research and training.

The building includes a state of the art solar and geothermal energy system and highly efficient heating and cooling.

[14] Science Park High School Chargers[2] compete in the Super Essex Conference, which is comprised of public and private high schools in Essex County and was established following a reorganization of sports leagues in Northern New Jersey by the New Jersey State Interscholastic Athletic Association (NJSIAA).

[15] The school competed in the Colonial Hills Conference prior to the NJSIAA's reorganization.

[18] The girls' outdoor track and field team won the Group I state championship in 1988-1990 and 1992.

[23] Trailing by as many as 20 points, the 1995 team won the Group I state title after defeating Burlington City by a score of 68-61 in the playoff finals.

[24] The boys' basketball team won the 2008 North II, Group I state sectional title with a 51-40 win over Bloomfield Tech High School in the tournament final.

By the early eighties, the Science HS Debate programs had nationally competitive teams.