Sclerophrys tuberosa is a species of toad in the family Bufonidae.

[3] The male advertisement call is a quiet, low-pitched "rrrou" or "rroua".

[3] Sclerophrys tuberosa inhabits moist lowland tropical rainforest in swampy areas, avoiding well-drained forest.

[3] Breeding takes place in small streams; the males call from cavities near water.

[1][3] Sclerophrys tuberosa is very common in parts of its range (e.g., Cameroon) but rarer in other areas.