They were first seen in public fighting off both the Sea Devils and the Challengers of the Unknown, in order to gain control over a living weapon of mass destruction known as the Sponge Man.
A field leader known as Agent Number Eight was responsible for duping the Sponge Man into attacking both the Sea Devils and the Challengers of the Unknown.
The Sponge Man had the ability to absorb water, and also any kind of energy: kinetic, heat, light, color, or sound.
Most recently, Scorpio shows up again in Power Company: Skyrocket #1 (set between the Challengers and Thunderbolt stories), where they kill the parents of Celia Forrestal.
Skyrocket and Green Lantern Hal Jordan captured several Scorpio members, but their field leader, a woman called Scorpia, escaped.