Most of the characters to use the Scorpio identity have been supervillains affiliated with the Zodiac criminal cartel, and in this context were enemies of the Avengers and other superheroes.

[10] In the final arc of the Secret Warriors series, it was revealed that Jake's death and much of his villainy was all part of a long-game plan of his brother's.

The real Jake, however, was in deep cover within HYDRA, co-opting the identity of the high-ranking agent known as Kraken and infiltrating the highest rungs of the organization and helping his brother bring about its destruction.

Impersonating LaPoint, Fury led eleven other Zodiac-themed androids to kill and replace the rest of the human Zodiac members, and took over the organization's criminal operations.

Scorpio and the other androids were deactivated when they were transported to the Zodiac Key's dimension of origin during a battle with the West Coast Avengers, and abandoned there.

Mikel originally believed himself to be Jake Fury's son, and used a duplicate of the Zodiac Key to battle his father and Wolverine.

[14] When he was led to believe that the Punisher had killed Nick, he pursued the vigilante until persuaded to back down by fellow S.H.I.E.L.D.

[17] The sixth Scorpio is an unnamed man with a half-burned face who Thanos recruited to join his incarnation of the Zodiac.

[22] When the planets that are shown in the Zodiac Grand Orrery get into alignment, Scorpio traveled back to his base in France.

While Spider-Man called his allies, Scorpio crashed the transmission stating that he will use his influence on Parker Industries enough to have it sink into the ground.

At the Royal Observatory, Scorpio places the Zodiac Grand Orrery in the prime meridian there and performed a ritual that opened a secret passageway underground.

When Scorpio steps into the door, he sees a year filled with events like Skyspear, Norman Osborn's latest activity, Regent's plot, the "New U" device, Doctor Octopus' return, another superhuman civil war, and the rise of the monsters.

[20] Jake Fury possessed a genius intellect, as well as basic army training, with an above average knowledge of hand-to-hand combat and streetfighting techniques.

The Ultimate Marvel version of Scorpio is mentioned to have been killed years earlier during a conflict in the Middle East, and now used by Nick Fury as an alias while undercover to infiltrate HYDRA.