In 2010, he began photographing and writing about sex workers in Skid Row, Los Angeles.
[7] Sothern has been in solo and group shows in NYC, Miami, and Los Angeles as well as Ottawa, London, Basel and Paris.
In 2013 and 2014, Scot wrote 52 photo-illustrated columns for Vice Magazine: Sothern Exposure[8] and Nocturnal Submissions.
[10] In 2011, The British Journal of Photography commenting on Lowlife wrote, "Scot Sothern makes this year's most controversial photobook".
[citation needed] Roger Ballen in 2021 opined, "Scot Sothern has bravely and empathetically entered a hidden world of humanity.