Stapp was a founding member and the original lead vocalist of American rock band Creed.

Stapp formed Creed with Tremonti in 1994, with fellow members Brian Marshall and Scott Phillips joining as bassist and drummer, respectively.

The album was followed in 1999 by Human Clay, which was an immediate success and certified diamond and eleven times platinum by the RIAA.

[11] It was announced that Stapp and Mark Tremonti would enter the studio to start recording new songs in June,[12] but no progress was made.

[14][15][16] On July 17, 2023, Creed announced they will reunite for their first shows in 12 years in 2024, when they set sail the "Summer of '99" cruise in April 2024 as headliners of the rock voyage.

[20] On August 18, 2010, Stapp wrote: "I'm stripping down all the Creed hits, as well as my solo material, in a manner fans have never heard before but have long been screaming for.

[31][32] In 2021, Stapp collaborated with electronic dance music artists Wooli and Trivecta on their song "Light Up The Sky", which was released on Ophelia Records.

[33] On May 3, 2016, Stapp announced that he would replace Scott Weiland (who died on December 3, 2015) as the lead singer of Art of Anarchy.

[37][38] In February 2018, it was reported that Stapp was being sued by Art of Anarchy for allegedly refusing to promote The Madness or tour in support of the album, having breached contractual obligations in the process.

[39][40] In December 2020, it was announced that Stapp would portray Frank Sinatra in a biopic film based on the life of U.S. President Ronald Reagan.

[41] In 2000, Stapp founded the With Arms Wide Open Foundation, a nonprofit organization "dedicated to helping underprivileged children and families around the world."

[42] In early 2012, to promote fundraising for victims of the 2011 Tōhoku earthquake and tsunami, Stapp and his wife, in cooperation with the U.S. Embassy in Tokyo, IsraAid, the U.S. Armed Forces, and the United Service Organizations, traveled to Japan and visited with victims of the tsunami in affected towns including Sendai and Ishinomaki along Japan's northeast coastline.

Stapp also performed an acoustic show on board the USS George Washington at the Yokosuka Naval Base for U.S. troops stationed in Japan to thank and express his appreciation for them.

[49] In a podcast interview with Theo Von, he claimed that his parents would physically abuse him "in the name of God", and that he'd live his life "on a timer", having to finish certain activities by a certain time to avoid further punishment.

[52] On February 11, 2006, Stapp married 2004 Miss New York USA winner and model Jaclyn Nesheiwat.

He retrieved two MP5s from his collection and put the guns to his head, but did not pull the triggers after looking at a picture of his son, Jagger.

He later said he had been convinced that anyone involved with Creed wanted him dead so he would become a "Kurt Cobain martyr-type" and increase record sales.

"[61] On Thanksgiving night of 2005, Stapp was involved in a fight with members of the band 311 at the Harbor Court Hotel in Baltimore.

[64] In March 2006, Stapp filed a lawsuit to block the release of a sex video involving himself, Kid Rock, and four women.

[65] The suit was settled in 2007, with the defendant agreeing to pay Stapp an undisclosed sum and to refrain from distributing the video.

According to Stapp, he jumped over a balcony and fell 40 feet, fracturing his skull and breaking his hip and nose.

[69] In a 2006 Rolling Stone interview, Stapp acknowledged that he had become addicted to Percocet, Xanax, and was withdrawing from prednisone for vocal cord inflammation during Creed's tour in support of Weathered.

He commented that the diagnosis was "a big sign [sic] of relief, because finally, we had an answer" about the reasons for his mental health difficulties.