During his senior year, Reynolds was named a McDonald's All-American, the first player in the Northern Region to be so honored since Joey Beard (South Lakes High School, Class of 1993).

[2][3] He signed a letter of intent to play for Oklahoma but was released by the university after their coach Kelvin Sampson left.

He was then recruited by Jay Wright of Villanova, playing in the Big East Conference of the NCAA.

Villanova made the Sweet 16 in the 2008 NCAA Tournament during Reynolds' sophomore season before losing to eventual champion Kansas.

During his Junior season, he was 2nd on the team with 15.2 PPG in leading Villanova to a 26–7 record and a #3 Seed in the 2009 NCAA Tournament.

During Villanova's Elite Eight matchup versus #1 seed Pittsburgh in the Tournament, Reynolds made a game-winning shot with 0.5 seconds to go to send Nova to the 2009 Final Four in Detroit.

[9] As a senior in the 2009–10 season, the 6-foot, 2-inch Reynolds averaged 18.5 points and shot 40 percent from 3-point range in becoming the Wildcats' go-to player with several spectacular second-half efforts.

Scottie Reynolds was the first AP All-American to not be selected in the NBA Draft since the NBA-ABA merger in 1976.

He averaged 10.3 points and 4.7 assists in the Suns' final three games of summer-league play after missing the first two with an Achilles injury.

[12] On October 26, 2010, it was announced that Reynolds was leaving Veroli after averaging 12.3 points, 2.5 assists and 2.3 steals to return to the US.

[14] On November 26, 2010, Reynolds scored 30 points and made the game winning three-pointer with 0.2 seconds left to give the Armor the 88–85 victory.

[19] On July 10, 2017, Reynolds signed with Russian club Zenit Saint Petersburg for the 2017–18 season.

[21] On January 4, 2019, Reynolds returned to Hapoel Holon for a third stint, signing as an injury cover for Khalif Wyatt.

[22] On September 4, 2019, Reynolds signed with newly promoted Greek Basket League club Larisa.