From an early age, Thompson began to learn ballet, jazz, and modern dance.

[3] After graduating, Thompson landed her first role in the television show Brotherhood (2006) opposite Jason Isaacs.

[1] She then guest-starred in several television shows before landing a recurring role on the CBS show NCIS (2006–2007) as Dr. Jeanne Benoit, the girlfriend of Tony DiNozzo (played by Michael Weatherly) and the daughter of Rene Benoit (played by Armand Assante).

She then filmed the independent movie Pornstar (2008), co-starring Matthew Gray Gubler of Criminal Minds, and made guest appearances on Shark (2007), CSI: NY (2007), and Eli Stone (2008).

In February 2010, Thompson was cast in the Brothers Strause alien-apocalypse film Skyline, which was released in November of that year.