The Scottish Junior Football East Region Premier League South also known for sponsorship reasons as the McBookie.com East Premier League South, was the second-tier division of the East Region of the Scottish Junior Football Association and sat parallel with the East Region Premier League North.

The league came into existence under the 'South' name for the 2006–07 season, although a 'Lothian District league' had been in place below the East Super League since 2002–03, using the structure of a common 'East Region' top tier and lower regional divisions in place of the old structure of three separate regional leagues in that part of Scotland, with the East Junior Football League the historic Lothians competition.

The South Division was expanded for the start of the 2013–14 season by absorbing the more southerly clubs from the dissolved East Region Central Division as part of league reconstruction in the region.

The large-scale movement of clubs to the East of Scotland League resulted in the structure being flattened into two tiers.

For the final season it comprised 10 clubs who were due to play each other three times to give 27 league fixtures prior to the season being cancelled due to the COVID-19 pandemic.