Scotus Central Catholic High School is a private, Roman Catholic high school in Columbus, Nebraska, United States.

It is located in the Roman Catholic Archdiocese of Omaha.

Scotus is the only Catholic high school in Columbus, and is the largest Catholic secondary school in Nebraska outside of Omaha or Lincoln.

The school was founded in 1884 as St. Francis Academy by the Sisters of St. Francis of Mary Immaculate of Joliet, Illinois, after the sisters added secondary grades to an elementary school they had founded in 1878.

The school was restructured in 1965 to include the support of other area Catholic parishes, and was renamed Scotus Central Catholic in honor of Franciscan scholar John Duns Scotus.