St. Francis High School was a private, Roman Catholic high school in Humphrey, Nebraska, United States.

It was located in the Roman Catholic Archdiocese of Omaha.

In early 2023, the Roman Catholic Archdiocese of Omaha announced that St. Francis High School and nearby Lindsay Holy Family High School would close via merger.

St. Francis was a member of the Nebraska School Activities Association.

St. Francis won the following NSAA State Championships:[1]