[1] This was the fifth selection of the renewed Señorita Panama pageant, under the direction of Cesar Anel Rodríguez, who took charge of the national event in 2016.

[4] However, in the face of the COVID-19 pandemic, the Señorita Panamá Organization decided to hold a prerecorded ceremony and broadcast on August 11, 2020, through the program Tu Mañana.

[6] This year, due to the COVID-19 pandemic, the contest was not held in person, however the Miss Universe Organization within its regulations establishes that if the national contest is not held, organizations may make a casting to choose a candidate or appoint by inheritance right the first finalist of the last edition.

On Friday, October 9, the winners of the virtual casting for Miss Supranational 2021 and Miss Grand International 2020 were announced, Darelys Yahel Santos Domínguez of Panamá Norte and Angie Keith of Bocas del Toro respectively.

On Friday, February 5, 2021, Valeria Estefanía Franceschi Alvarado from Panama Centro was announced the winner of the Señorita Panamá International 2020 title.