This was the sixth edition of the renewed Señorita Panama pageant, under the direction of Cesar Anel Rodríguez, who took charge of the national event in 2016.

[2] The 2021 edition was held, for the first time, Hotel Whyndham Convention Center, in Panama City on November 7, 2021.

[6] On 26 November, the Señorita Panamá Organization announced Ivis Nicole Snyder as the Señorita Panamá for 2022 for represented her country at the Miss International 2022 pageant after the organization lost the right of Miss Universe pageant and succeeded outgoing Señorita Panamá 2021 Brenda Smith Lezama.

Held on November 5, the Gala Viva Panama was the election for the Best National Costume.

The event showcased the creative work of Panamanian designers and also selected the costume for Panama at Miss Universe 2021.