The company has a main focus on Protein Engineering projects based on the QuESt (Quality Enzyme Solutions) strategy and gene library generation using its patented platform technology Sequence Saturation Mutagenesis.

The SeSaM-Biotech GmbH was founded in 2008 as a spin-off of Jacobs University Bremen by Prof. Ulrich Schwaneberg who had developed and improved the patented key technology Sequence Saturation Mutagenesis (SeSaM) in the preceding years,[1][2][3] In 2012, SeSaM-Biotech moved to its new facilities at the Leibniz-Institute for Interactive Materials (DWI) in Aachen.

[5] Besides, internal research is performed for the further development of the in-house techniques and the expansion of the product range beyond protein engineering service provision.

SeSaM has been developed by Prof. Schwaneberg and his group in order to overcome several of the major limitations encountered when working with standard mutagenesis methods based on simple error-prone PCR (epPCR) techniques.

Besides, SeSaM-Biotech offers single enzyme services for assay development, computational analysis and in the consulting sector.