Seabrook is an unincorporated community and census-designated place (CDP) located in Beaufort County, South Carolina, United States.

[3] Situated in northern part of the county along the Whale Branch River, Seabrook was founded in the late 18th century as a collection of plantations became established in the area.

In the late 19th century, Seabrook became a stop on the Port Royal and Augusta Railway and featured a small, but bustling downtown area that had a federal Post Office, a general store, a gas station, and a train station.

In the past ten years, three new public schools have opened in the Seabrook area to serve area students, including Whale Branch Early College High School.

The McLeod Farmstead was listed on the National Register of Historic Places in 1997.