Seattle Syndrome Volume One is a compilation of Seattle-based bands and artists released on vinyl and cassette in late 1981 on Engram Records.

[1] Supervised by former Telepaths guitarist Homer Spence, Danny Eskenazi (who also bankrolled the project) and local promoter Neil Hubbard, and recorded and engineered by Jack Weaver, the compilation features many of the well-known bands of the late seventies and early eighties music scene of Seattle, as well as including bands from Washington state.

[2] Hardcore punk bands The Fartz (who would later evolve into Ten Minute Warning, also of considerable influence on the following generation of Seattle underground rock bands) and The Refuzors contribute songs as well as long-lasting pop punks, The Fastbacks (then with a teenaged Duff McKagan on drums who would later join the Fartz and then be a formative member of Guns N' Roses).

"[4] However, due to the then underdeveloped touring and promotion circuit for underground music, almost all of the bands who left Seattle for other cities – such as the Blackouts (who relocated to Boston, with some of their members later joining Ministry), art-punks Chinas Comidas (Los Angeles) or glam punk band The Fags (New York City) – only found little success abroad and split up shortly afterwards.

[3] Mark Baumgarten calls the record "a definitive compilation of songs documenting the city's punk and new wave scenes that was highly influential to the bands that went on to form the nucleus of the grunge movement".