Sebastián Calderón Centeno (born 20 January 1946) is a Mexican politician affiliated with the National Action Party (PAN).
In 2006–2012 he served as a senator in the 60th and 61st sessions of Congress, representing Campeche.
He also served as a federal deputy in the 59th Congress (2003–2006), representing Campeche's 2nd district.
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