He is known for his roles as Kurt Mendel in Odyssey 5, Jerry Jacks in General Hospital, Thomas Jerome Newton in Fringe, Balthazar in Supernatural, Mikael in both The Vampire Diaries and The Originals, and Reichsminister Martin Heusmann in The Man in the High Castle.

Roché has appeared in the films The Last of the Mohicans (1992); The Peacemaker (1997); 15 Minutes (2001); Sorry, Haters (2005); The Namesake (2006); New York City Serenade (2007); Beowulf (2007); Happy Tears (2009); Safe House (2012); Wer (2013); A Walk Among the Tombstones (2014); and We Love You, Sally Carmichael!

[4] Roché began his acting career in the made-for-television film The Murders in the Rue Morgue, appearing opposite Ian McShane and Val Kilmer, which aired on CBS on 7 December 1986.

In 1997, Roché was part of the main cast in the Fox fantasy adventure series Roar, playing the role of Saint Longinus.

Roché's many 1990s television credits include recurring and guest starring stints in series such as Feds (1997), Dellaventura (1997), Sex and the City (1998), Merlin (1998), Law & Order (1993 & 1999), and Big Apple (2001).

He subsequently co-starred with Freddie Prinze, Jr. the comedy-drama New York City Serenade, which premiered at the Toronto International Film Festival on 13 September 2007.

Roché next starred in the motion capture epic fantasy film Beowulf, alongside Anthony Hopkins and Angelina Jolie, which was directed by Robert Zemeckis and released to cinemas on 16 November 2007.

[20] Roché next had a supporting role in the action-thriller film Safe House, starring Ryan Reynolds and Denzel Washington, which was released on 10 February 2012.

[26] In December 2014, it was announced that Roché would guest star in season four of ABC's fairy tale drama series Once Upon a Time as King Stefan.

[27] Roché starred as Pierre Curie in an episode of the documentary miniseries The Mystery of Matter: Search for the Elements, which aired on PBS on 19 August 2015.

[29] In 2016, Roché co-starred as Cardinal Michel Marivaux in Paolo Sorrentino's drama series The Young Pope, alongside Jude Law and James Cromwell.

[30] He also had a starring role in the second and third season of Amazon Video's drama series The Man in the High Castle as Martin Heusmann, the estranged Nazi father of main character Joe Blake (Luke Kleintank).

[33] Roché performed in a modern-day adaptation of the Molière play Tartuffe, making his West End theatre debut as Orgon.

[35] He appeared in Tides directed by Tim Felhbaum opposite Iain Glen and Nora Arnezeder as well as the Michael Bay film 6 Underground with Ryan Reynolds for Netflix.

Roché also shot the NBC pilot Getaway and can also be seen in Guillermo del Toro's Cabinet of Curiosities as Roland, opposite Tim Blake-Nelson.