Sebastiano Lo Monaco (1750–1800) was an Italian painter active in Sicily during the Rococo period.
He frescoed extensively with Matteo Desiderato in the Palazzo Biscari of Catania, including the cupola in the Loggia dei Musici, painted with a Triumph of the Biscari Family.
He later moved to live in Sortino, where he frescoed the church of the Natività di Maria.
Other works of Lo Monaco are found in Lentini, Ragusa, Mineo, Militello in Val di Catania, Siracusa, and Biancavilla.
This article about an Italian painter born in the 18th century is a stub.