Sebastiano Mazzoni (c. 1611 - Venice, 22 April 1678) was an Italian painter of the Baroque period.
Born in Florence, he trained in that city during 1632-33 in the studio of Baccio del Bianco.
He painted a somewhat unusual Annunciation with a hovering ghostly angel dominating the scene.
Andrea Celesti was one of his pupils; and it is said he influenced the style of Sebastiano Ricci and Ghislandi.
Ultimately he has an enigmatic individual style with paintings of unresolved dynamism, depicted from awkward perspectives, in some fashion he resembles his contemporary Francesco Maffei or evokes the distortions of a Lorenzo Lotto of the prior century.