In March 1453, the venetians commanded by Jacopo Piccinino started the reconquest of the Bassa Bresciana, reaching the town on May 25th, when the Duke was in Cremona.

On May 25th, Piccinino placed the bombards in front of the castle and he made his men camp along the two banks of the Oglio river, then he started the siege of the fortress.

The duke, as soon as he learned of the siege, gathered an army in Cremona and headed towards the Castle of Seniga, which was still under his control and where were located many milanese soldiers, to move to Pontevico encircling the besiegers.

In the fourth day of siege, on May 29th, Jacopo Piccinino decided to incite his soldiers promising them that, in case of victory, they could loot the town and take revenge on their enemies.

On August 15th, the milanese army conquered Ghedi Then, in autumn, Francesco Sforza get numerous military reinforcements from France and Florence, conjoining with Renè of Anjou forming an army of around 25.000 among knights and infantrymen: they encircled the town and sieged his castle between October 16th and 19th, conquering it after three days of siege.