The game also featured a campaign mode, similar to that found in Their Finest Hour, where the player had to make the strategic decisions on which targets were to be attacked (as USAAF 8th Air Force) or defended (by the German Luftwaffe).

The game sets up German secret weapons, with fast jet propulsion and a variety of missiles and bombs, against slower but more numerous American piston-engined airplanes.

In Tours of Duty, the player creates his own pilot (or crew, for B-17 Flying Fortress) and fights in the air war for a limited number of missions (from 25 to 55, according to the historical Squadrons).

The pilot/crew gain experience points, ranks and decorations; and if he manages to survive his assigned Tours of Duty, he can even start another, without time limitations.

The game features a numerous set of prebuilt, historically-oriented missions in which the player is free to choose their own pilot and/or crew.