The Secretariat of Health (Spanish: Secretaría de Salud) is the government department in charge of all social health services in Mexico, and an integral part of the Mexican health system.

The Secretary of Health is a member of the Executive Cabinet and is appointed at the discretion of the President of the Republic.

In recent years, the Secretary of Health has played a more restricted role, as many of its functions have been transferred to the corresponding institutions of the individual Mexican States.