Sedamsville was established in 1795 by Colonel Cornelius Sedam, a veteran of the Revolutionary War, who moved to the area to assist in the building of Fort Washington.

[5] The Industrial Revolution changed the landscape bringing commerce and large factories to the area along with a new influx of residents.

Unfortunately the Great Depression saw many of those businesses close their doors, and then the disastrous flood of 1937 made it impossible for many to rebuild.

[citation needed] The neighborhood further declined in the late 20th and early 21st century due to negligent landlords owning several of the area's buildings.

[7] According to the U.S. Census American Community Survey, for the period 2016-2020 the estimated median annual income for a household in the neighborhood was $45,568.