Along with Primero, Tercero, Cuarto, Quinto, and Sexto, Segundo is one of the municipality's six core urban barrios.

[3] Barrio Segundo has 3 subbarrios: Baldority de Castro (or just "Baldorioty"), Clausells,[a] and Reparada.

Segundo is home to a large number of Ponce's landmarks and historic sites.

Plaza Las Delicias, 25 de Enero Street, and Paseo Atocha, are located there.

The NRHP-listed Parque de Bombas, Nuestra Señora de la Guadalupe Cathedral, Armstrong-Poventud Residence, Casa Wiechers-Villaronga (Architecture Museum), Panteón Nacional Román Baldorioty de Castro, Albergue Caritativo Tricoche, Casa Miguel C. Godreau, and Subira House are all located in Barrio Segundo.