Modeled after the traditional late-night talk shows of the U.S., the show incorporates the use of comedy bits, monologue jokes, musical guest performances as well as celebrity interviews.

Seifu on EBS follows the already established six-piece late night format popularized by many late-night talk show hosts of United States.

Each episode of Seifu on EBS is 90 minutes in length, including commercials, and typically consists of: Seifu starts each episode with a monologue drawing from current news stories and issues.

The monologue is sometimes accompanied by pictures and videos found on social media.

Following the monologue, Seifu usually interacts with the audience through games or takes part in comedy sketches involving a guest on the show.