Leaving the Lindre lake, it skirts the town of Dieuze, and traverses Vic-sur-Seille and Nomeny, before flowing into the Moselle at Metz.

Since the Middle Ages, there has been much work performed on the Seille, in part to straighten it (to render it navigable), to drain the nearby swamps, and to limit flooding of adjacent low-lying areas.

Despite this, the valley is of biological interest: salt water resurgences have led to the presence of various plant species that are usually confined to coast lines, including glasswort, aster tripolium, and sea-spurreys.

This section of the river has comparatively few tributaries: Finally, in Metz, after passing the Porte des Allemands (a 13th-century castle, lit.

Some examples include: Aboncourt-sur-Seille, Aulnois-sur-Seille, Bey-sur-Seille, Brin-sur-Seille, Coin-sur-Seille, Haraucourt-sur-Seille, Mailly-sur-Seille, Malaucourt-sur-Seille, Moncel-sur-Seille, Morville-sur-Seille, Port-sur-Seille, and Vic-sur-Seille.