Sekhmakh was the wife of the Nubian king Nastasen, who ruled in the 4th century BC.

[1] Sekhmakh is known from the great stela of the king, where she is depicted in the roundel.

She is also known from her funerary stela,[2] found in a temple at Jebel Barkal and obviously reused.

Sekhmakh bears the titles king's daughter, king's wife and mistress of Egypt.

Sekhmakh had a Horus name and is referred to as "king" on a stela from Jebel Barkal, possibly indicating that she was a queen regnant or had some kind of role that was a precursor to the reigning queens of Meroë.