Self-portrait with the Colosseum is a 1553 painting by the Dutch Golden Age artist Maarten van Heemskerck in the Fitzwilliam Museum.

It is signed and dated lower center MARTYN VAN HEMSKER AO AETATUS SUA LV 1553.

Heemskerck painted it upon his arrival in Italy whereupon it came into the collection of Anton Perrenot de Granvella (d. 1586).

The image of the Colosseum has been identified with an undated sketch currently in Berlin that itself was a model for Pieter Jansz.

[3][4] Many of these were later engraved and published by Philips Galle in 1569 as the Clades series, or Inventiones Heemskerkianiae Ex Utroque Testamento.