His son, Samuel Sellers, Jr. (1690–1773) continued to develop American wire-working and invented machines for the twisting of worsted yarn.
Like their descendants, both Samuels were members of the Society of Friends, whose tolerant policies and commitment to reason encouraged scientific and mechanical pursuits.
Nathan Sellers initiated his family's involvement in the anti-slavery movement, which would continue in concert with the Garrett, Pennock and other closely related Pennsylvania families, until the practice of slavery was abolished, not only in Pennsylvania, but throughout the United States.
He pioneered principles of scientific management and efficiency in cooperation with his chief engineer, Frederick Winslow Taylor (1856–1915).
The history of the Sellers family of scientists and engineers is extensively documented by the Peale/Sellers Collection of the American Philosophical Society.