The municipality benefited from the construction of Napoleon's imperial road from Paris to Mainz, which placed the town on a supra-regional transport route and made it a post station in 1809.

As a result of the resolutions passed at the Congress of Vienna in 1815, Sembach first became part of Austria and a year later the Rhine district in the Kingdom of Bavaria, which later became the Palatinate.

After the Second World War, Sembach became part of the newly formed state of Rhineland-Palatinate within the French occupation zone, ending its affiliation with Bavaria.

Neighboring municipalities are - clockwise - Wartenberg-Rohrbach, Münchweiler an der Alsenz, Gonbach, Neuhemsbach, Enkenbach-Alsenborn, Mehlingen and Otterberg.

Many other buildings consist of Sembach Annex accomplishing a variety of missions for the United States Air Force.

The former runway has been mostly dismantled except for a small stretch at the eastern end with the remainder of the former facility now being an industrial park.

An article dated 26 January 2010 in the Stars & Stripes stated the facility would be turned over to the U.S. Army by the end of fiscal year 2010 (30 Sep 2010)[1]