Weilerbach was first mentioned in a document from 1214, in which King Friedrich II gave the right of patronage to his loyal Reinhard von Lautern, knight of Hoheneck, for the parish church at Ramstein with its daughter church in Weilerbach (Wilrebach) und Spesbach (Spethisbach).

In 1253, Siegfried von Hoheneck gave these rights and the income therefrom to the Teutonic Order in Kaiserslautern.

Pope Alexander IV confirmed in 1258 the Order's possession of Ramstein, Weilerbach, und Spesbach.

The old roads from Kaiserslautern to Kusel and from Zweibrücken to Bingen am Rhein intersected in Weilerbach, causing the establishment of a customs station under the Electoral Palatinate.

In 2008, the Department of Defense approved $400 million to expand and renovate the existing hospital, contingent upon congressional support for the funding.

In 2010, the proposal was changed to total replacement and relocation from Landstuhl to Weilerbach,[7] with increased funding of up to $1.2 billion (USD).

[8] Some Germans who deem the wars in Iraq and Afghanistan illegal and are opposed to continued US military presence in Germany consider the significant financial commitment to medical facilities to imply an intention for long-term occupation.