Sempronia was an Ancient Roman woman of the late Republic who was the wife of Decimus Junius Brutus, the consul of 77 B.C.

[9] Sempronia was described as a distinguished, witty, beautiful, accomplished, and passionate woman, who spoke Greek and Latin.

Without the knowledge or consent of her husband, she participated in the conspiracy of Catiline and allowed the conspirators to meet in her home to plan.

[20] She is the title character of the short story "The Consul's Wife" by Steven Saylor where she and her lover are plotting to have her husband murdered.

[23] In the novel Respublica: A Novel of Cicero's Roman Republic Sempronia is portrayed as a vile woman who murders her husband and mentally and sexually abuses her son Decimus.