Semur-en-Brionnais (French pronunciation: [səmyʁ ɑ̃ bʁijɔnɛ]) is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France.

It is a member of Les Plus Beaux Villages de France (The Most Beautiful Villages of France) Association.

Semur-en-Brionnais is the birthplace of

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