[8] After the arrival in 1498 of the Portuguese explorer Vasco da Gama on an Mozambique island in his search of a sea route to India, the colonial influence began on Sena and other ethnic groups in this part of Africa.
[9] Few years later, a storm hit a caravan of the ships of his countryman Pedro Álvares Cabral trying to repeat Vasco da Gama's voyage, separating them.
Their reports triggered a gold rush and a commitment by Portugal king to settle Mozambique region where many ethnic groups including the Sena people lived.
[10][9] In 1514, Antonio Fernandez confirmed there were rich goldfields in middle Zambezi valley, the traditional home of Sena people, and the Portuguese interest in colonizing this region grew.
[11] Starting with the 16th century, Portuguese traders, farmers and missionaries arrived in the Zambezi valley (stations in Sena, Tete, Zumbo, Quelimane).
The Portuguese settlers built farm estates in the river valleys, working them with African labor which included the Sena people.
[7] In 1531, Vicente Pegado founded a fair in a Muslim village along the Zambezi river, which then grew to become a major trading post, missionary center, colonial era garrison and market town.
[11] By late 16th century, particularly after Francisco Barreto 1569-1575 expedition, the Portuguese had gained control of all the major mining and trading regions along the Zambesi valley where Sena people have lived.
[17] Official documents of the Governor-general Joaquim Pereira Marinho from 1840-1841 period state everyone was involved in this slave trading operations, from Portuguese to Moors, women of all ages, clergymen, civilians and soldiers in the Portuguese colony; it also describes how mujojos, or "dark Moors" would invade to steal slaves and export them from different ports and the Island of Mozambique.
[19] These developments stabilized the lives and family units of the Sena people and other ethnic groups in the Zambesi valley as well as the rest of Africa.
During the scramble for Africa the weakened Portuguese crown leased this region to British companies, which built the railway connections between the Indian Ocean and their colonies, in this case the TZR, Trans-Zambezi-Railway, between Beira and Njassaland/Malawi via Sena.
[citation needed] According to Kevin Shillington, Portuguese colonisation of the region developed from about 1505 through the 19th century, but it was never accepted by Sena people and other Africans.
Similar to neighboring ethnic groups in Mozambique, wedding among Sena people of river valley regions required a brideprice called lobolo which was a payment made to the family of the bride to compensate them for the loss of her work output in her birth home.