[6] Fisseha was born in Addis Ababa, Ethiopia, where she briefly studied at Tikur Anbessa (Black Lion Medical School) [7] before, relocating to the United States, Rosary College (now Dominican University), where she earned her Bachelor of Science degree.

[7] She finalized her residency in obstetrics and gynecology and completed a fellowship in reproductive endocrinology and infertility at the University of Michigan medical center.

[9] After the completion of her fellowship at the University of Michigan, she joined the institution as junior faculty and later earned a tenure track position, which resulted in a full professorship.

[10] During her tenure  at the University of Michigan, Fisseha occupied numerous  academic and administrative positions, including medical director of Michigan's Center for Reproductive Medicine, chief of division for reproductive endocrinology & infertility, and as the co-director of the medical school's Path of Excellence in Global Health & Disparities.

[10] Fisseha established the Center for International Reproductive Health Training (CIRHT) at the University of Michigan in 2014 and she remained its executive director until 2015.

Throughout the COVID-19 pandemic, Fisseha emerged as a prominent advocate addressing global health disparities related to policy and vaccine distribution.

She was the founder and co-chair of the first International Conference on Public Health in Africa (CPHIA) which was held virtually in December 2021 during the COVID-19 pandemic.

[1] Senait met her husband Tewodros Fesseha M.D., a Urology Robotic Surgeon, while she was conducting research at the University of Michigan.