Formerly known as the Niagara Falls Convention and Civic Center, it was sold to the federally recognized Seneca Nation of New York.

Upon its opening, the New York Times described the tower as "the skyline on the American side of the Niagara River.

[9] The Seneca Niagara Casino & Hotel is home to the Seneca Niagara Events Center, a 2,400-seat theater that has hosted various performing artists, including Stevie Nicks, Tony Bennett, Aretha Franklin, Martina McBride, Trace Adkins, Lewis Black, Lisa Lampanelli, Steely Dan, Heart, Steve Miller Band, Huey Lewis and the News, Gretchen Wilson, Air Supply, Smokey Robinson, Diana Ross, Blondie, Jeff Foxworthy, Jay Leno, The Moody Blues, Grand Funk Railroad, Cheap Trick, Jim Gaffigan, New Kids on the Block, Seth Meyers, The Pointer Sisters, Chicago, The Go-Go's, Bobby Vinton, Tracy Morgan, Jackson Browne, Frank Caliendo, Michael Bolton, Alanis Morissette and more.

[citation needed] In addition, the Seneca Niagara Casino & Hotel has the Bear's Den Showroom, a 440-seat theatre that presents more intimate shows, such as The Goo Goo Dolls, Eddie Money, The Grass Roots, Lou Gramm, Gary Lewis and the Playboys, Little River Band, Mary Wilson, Richard Marx, and more.

The former Convention Center is located on sovereign land, and the casino is operated by Gaming Corporation.

In 2023, the resort was ranked sixth on a list of the Ten Best Casinos Outside Las Vegas by USA Today in their 10 Best Readers Choice Awards.