Seneca One Tower is a 529-foot (161 m) skyscraper located in downtown Buffalo, New York.

Paired with the departure of Phillips Lytle LLP, and the recent closing of the Canadian Consulate, the tower was 90 percent vacant as of 2014.

[14][15] In August 2016, it was announced that Washington, D.C.–based Douglas Development will buy One Seneca tower.

[16] On September 29, 2016, Buffalo Business First reported that Douglas Jemal of Washington, D.C. had completed the purchase of One Seneca Tower and an adjacent parking ramp with plans to redevelop the tower and plaza into a mixed-use complex including retail, restaurant, hotel, office and apartment components.

[18] In early 2021 an illuminated M&T Bank sign was added to the top of the building, replacing a Buffalo Bills pennant (a promotional courtesy of the local Oxford Pennant Company) that was temporarily introduced for the team's 2020 season playoff run between the AFC Wild Card and AFC Championship rounds.