Senotherapeutics refers to therapeutic agents/strategies that specifically target cellular senescence.
[1] Senotherapeutics include emerging senolytic/senoptotic small molecules that specifically induce cell death in senescent cells [2] and agents that inhibit the pro-inflammatory senescent secretome.
[3] Senescent cells can be targeted for immune clearance, but an ageing immune system likely impairs senescent cell clearance leading to their accumulation.
[4] Therefore, agents which can enhance immune clearance of senescent cells can also be considered as senotherapeutic.
[citation needed]