Senotherapy

Senotherapeutics refers to therapeutic agents/strategies that specifically target cellular senescence.

[1] Senotherapeutics include emerging senolytic/senoptotic small molecules that specifically induce cell death in senescent cells [2] and agents that inhibit the pro-inflammatory senescent secretome.

[3] Senescent cells can be targeted for immune clearance, but an ageing immune system likely impairs senescent cell clearance leading to their accumulation.

[4] Therefore, agents which can enhance immune clearance of senescent cells can also be considered as senotherapeutic.

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