[4] Pursuing genocide as the means of dealing with a threat has made the Sentinels an analogy for racial hatred and other negative types of fanaticism in Marvel stories,[5] represent the horrific consequences of humanity's actions based on hate and ignorance, along with a caution of the risks of AI takeover.

They are armed (primarily with energy weapons and restraining devices), capable of flight, and can detect mutants at long range.

[34][full citation needed] Later, the Sentinels are adapted by Weapon Omega to serve a reverse purpose, and now aid in the hunting of the human race.

[volume & issue needed] In the joke comic Fred Hembeck Destroys the Marvel Universe, the X-Men are killed by silent, black, man-sized "Ninja Sentinels".

The Sentinels are adapted by Sebastian Shaw, now the director of S.H.I.E.L.D., to serve a reverse purpose, and now aid in the hunting of sapien rebels.

[volume & issue needed] In the MC2 timeline, Wild Thing encounters a Prime Sentinel that has accidentally been activated by a faulty microwave.

[volume & issue needed] In the comic crossover X-Men/Star Trek: Second Contact, the X-Men work with the crew of the Enterprise-E to battle Kang the Conqueror.

An away team composed of Captain Picard, Deanna Troi, Nightcrawler and Colossus encounter an approximation of the "Days of Future Past" timeline, in which the Sentinels have merged with the Borg.

[36][full citation needed] In 2020, Brooklyn rapper Magneto Dayo unveiled "The Sentinels", a project that gained viral traction on Instagram reels in 2024, amassing over 5 million plays.