A major transportation nexus, it is transected by the Gyeongbu, Guma, and Jungang Expressways.

It is also connected to the downtown region and to Dalseong County by Daegu Subway Line 2.

The Gyeongbu Line railroad also passes through Seo-gu, but no major stations are located there.

Seo-gu stands at the western edge of Daegu's urbanized region.

Most of the western third of Seo-gu is taken up by the rural Sangjungi-dong precinct.