Portions of Sepulveda Boulevard between Manhattan Beach and Los Angeles International Airport (LAX) are designated as part of State Route 1 (SR 1).

The southernmost of the four segments is an east-west route located in the South Bay, and continues west as Camino Real in Torrance and east as Willow Street in Long Beach.

The third segment runs from LAX, through the Westside regions, and over the Santa Monica Mountains at the Sepulveda Pass into the San Fernando Valley.

The northernmost section of Sepulveda Boulevard is in Sylmar, running from Roxford Street north to San Fernando Road.

The party had been travelling west, intending to reach and follow the coast, but were discouraged by the steep coastal cliffs beginning at today's Pacific Palisades and decided to detour inland.

[3] Sepulveda Boulevard was named in 1925 after 18th century cattle rancher Francisco Xavier de Sepúlveda, whose ranch, Rancho San Vicente y Santa Monica, extended from the route to the Pacific Ocean.

[8] In 2018, the city of El Segundo also decided to formally change the name to Pacific Coast Highway to better appeal to visitors as being a coastal community.

[11] Past Imperial Highway, it crosses the western terminus of the Century Freeway (I-105), going through the LAX Airport Tunnel to pass under its runways.

The road then passes through an interchange with Century Boulevard, which provides access to LAX's terminals to the west and the San Diego Freeway (I-405) to the east.

Sepulveda Boulevard then runs parallel to the east of I-405, crossing the Ventura Freeway (US 101) and the Los Angeles Metro G Line rapid transit route, and through the San Fernando Valley communities of Van Nuys and North Hills, to its northern terminus at the Rinaldi Street interchange with I-405 in Mission Hills.