Seraphim II was born in Delvinë, located in modern-day southern Albania in the late 17th century.
[1] As Patriarch in 1759 Seraphim II introduces the feast of Saint Andrew on 30 November,[4] and in 1760 he gave the first permission to Kosmas the Aetolian to begin missionary tours in the villages of Thrace.
[5] In 1759 Seraphim II invited Eugenios Voulgaris to head the reforms in the patriarchal academy and during his tenure in the academy influenced by Seraphim's pro-Russian ideals, Voulgaris contributed to the reapproachment of the Russian Empire with the Ecumenical Patriarchate of Constantinople.
[6][7] As a consequence Seraphim II was deposed on 26 March 1761 and exiled on Mount Athos,[1] and he was replaced by the Ottoman authorities with Patriarch Joannicius III of Constantinople.
[8] On the field of politics, he supported the Russian Empire during the Russo-Turkish War (1768–1774) and the establishment of an Orthodox pro-Russian state in the Balkans.