Serapion (Russian: Серапион; died March 16, 1516) was Archbishop of Novgorod the Great and Pskov from 1506 to 1509.
He is a saint of the Russian Orthodox Church; his feast day is March 16 by the Julian calendar.
With the consent of Great Prince Vasily III of Moscow, he was consecrated Archbishop of Novgorod on January 15, 1506, but only served a little over three years.
In July 1509, at the Sobor that considered the conflict between him and Joseph Volotsky (the latter was under Serapion's episcopal jurisdiction but had directly appealed to Simon, Metropolitan of Moscow - an act that Serapion deemed to be uncanonical), and his letter of complaint, in which he said Joseph had abandoned heaven (meaning he had abandoned his rightful bishop) and descended to earth.
Sources claim he made peace with Volotsky and others, but there is some evidence that he remained bitter at his removal to the end of his life.