Serena (died 409) was a member of the Theodosian dynasty as the niece of the emperor Theodosius I, as well as the wife of the military commander Stilicho.

[3] The poet Claudian stated that the union had been arranged by Theodosius due to Stilicho's military capability, but some modern scholars have disputed this.

Zosimus reported that during Theodosius I's visit to Rome in 394, Serena, a Christian, took a necklace from a statue of Rhea Silvia and placed it on her own neck.

[7] Alan Cameron and John Matthews are both skeptical of the entire tale,[8] believing that Theodosius' reported visit to Rome should be rejected.

In the following year Serena was falsely accused of conspiring with the Visigoths besieging Rome, and was executed with Galla Placidia's consent.